Endocrine Society Announces New Clinical Practice Guideline To Identify People At Metabolic Risk

Endocrine Society Announces New Clinical Practice Guideline To Identify People At Metabolic Risk

Finally, they’ve woken up and smelled the coffee! Obesity is not the issue, metabolic health is.

But there are three other markers that are important: fasting insulin, uric acid, and ALT.

-Dr. Robert Lustig

Endocrine Daily Briefing – From the Endocrine Society

Endocrine Society Issues New Clinical Practice Guideline To Identify People At Metabolic Risk

Medscape (7/31, Busko, Subscription Publication) reports, “By screening for five simple markers – waist size, blood pressure, HDL cholesterol, triglycerides, and glucose/HbA1C – during office visits, clinicians could identify high-risk adults who need to improve their lifestyle to prevent cardiovascular disease or type 2 diabetes [T2D],” experts recommend in a “new clinical practice guideline – ‘Primary Prevention of ASCVD and T2DM in Patients at Metabolic Risk’ – issued by the Endocrine Society and published online July 31 in the Journal of Clinical Endocrinology and Metabolism.” Included in the new guideline is “the American Heart Association/American College of Cardiology Pooled Cohort Equation to calculate 10-year risk for atherosclerotic disease.”

Endocrine Today (7/31, Schaffer) reports the guideline states, “The Endocrine Society has recognized the importance of identifying individuals who are at metabolic risk so that efforts can be instituted to prevent both [atherosclerotic] CVD and [type 2 diabetes].” In particular, the guideline “addresses individuals with components of metabolic syndrome who do not yet have diagnosed atherosclerotic CVD or type 2 diabetes and the steps that can be taken to prevent these two diseases.” In addition, it “focuses on behavioral, nutritional and medical management.”

According to Endocrine News (7/31, Seaborg), “the original Endocrine Society guideline on this topic was published in 2008.” This revision, however, “takes a fresh look at metabolic risk and presents recommendations which reflect more recent trial data on blood pressure and lipids,” prioritizing “lifestyle and behavioral interventions” while discussing “new medical treatment options.” Even though “the guideline is targeted towards adults aged 40 to 75,” it “can be used to guide patients outside of this age range as well.”

 Also covering the story are the Endocrinology Advisor (7/31, Beairsto) and Clinical Endocrinology News (7/31, Splete).

Read more:

Healio: Endocrine Today

The Juice PR Machine

The Juice PR Machine

How scared is the juice industry? Nothing wrong with their making a critique, just remarkable to see what lengths they will go to squelch dissent.

From the resistance… a letter received from the Juice Products Association:

It’s a trend we are all seeing – more and more studies are being conducted and published without pre-specified analysis. Researchers test connections unsystematically and publish only positive results. Our standards for how we conduct and communicate nutrition research to the public are slipping.

Last week a study was published, by the British Medical Journal that suggests that drinking 100% juice is linked with an increased risk of cancer.  As you know, a person’s health is dependent upon the totality of their diet and lifestyle – not one specific food or beverage.  Studies such as this one do not prove cause and effect yet that is what headlines scream.

Furthermore, these results contradict several other studies, including large U.S. cohort studies, concerning 100% fruit juice consumption and cancer, which shows no association with increased risk. In fact, 100% fruit juices contain bioactive compounds that have been shown to have anti-carcinogenic properties in some studies, (Veselkov et al. Scientific Reports. 2019;9:9237).  

There were a number of limitations with the NutriNet-Santé study published last week.  These include, but are not limited to:

  • The study is observational and, as such, is unable to show cause and effect, only associations.
  • The study was based on a French cohort and not representative of US culture, dietary patterns and eating styles.  It is also not indicative of typical consumption patterns seen in the United States regarding sugary drink consumption.
  • Much of the data was obtained through self-reporting, which introduces errors
  • The mean follow-up time (about 5 years) is very short for a cancer study
  • These results cannot be applied to a general population as the cohort was overwhelmingly female (almost 79%)

Together, we can make our voices heard against bad science. I am commenting on news coverage regarding this study in order to educate the public and consumers who are confused about nutrition. I urge you to join me in speaking out against studies like this that are not based on scientific best practices and cause unnecessary consumer confusion.

For more information, visit SipSmarter.org. Please don’t hesitate to contact me directly if you have any questions, concerns, or need any other information.  I would be happy to discuss.

Sincerely,

Diane Welland MS, RD

Juice Products Association

www.sipsmarter.org

 

What about fruit juice?

Fruit Juices Are Basically Just Liquid Sugar

Fruit juice products are exploding and it seems like most people believe fruit juices are healthy…they come from fruit, so they must be OK?

Unfortunately, many of the “fruit” juice products you find in the supermarket aren’t even fruit juice, just fruit flavored beverages imbued with chemicals that taste like fruit. Many of these products are basically fruit-flavored sugar water.

Even if you’re drinking 100% fruit juice (organic, natural, made in your own juicer, blah, blah, blah), it is still a problem. Fruit juice often has had the fiber taken out or destroyed and the main thing left is the sugar, now concentrated. Despite their healthy image and brilliant marketing, many fruit juice products contain the same amount of sugar as sugar-sweetened beverages.

A typical glass of orange juice contains 4 oranges. One serving of orange juice (an 8-ounce glass) contains 22 grams of sugar. By comparison, 8-ounces of Dr. Pepper (pick your soda) contains 27 grams of sugar. 

One simple solution is not to drink your calories. Eat whole fruit – with the fiber. Try “spa water” recipes that use small amounts of fruit for flavoring. And when you absolutely need some juice, than make it a small glass.

How many oranges have you consumed in one sitting? The fiber in whole fruit increases satiety and also helps to metabolize the sugar in healthy ways. Since our diet is already so overloaded with sugar, big blasts of sugar tend to be bad for our metabolic health.

Review of Processed Food Study by Kevin Hall

Review of Processed Food Study by Kevin Hall

Review of recent study published in Cell Metabolism:

Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake. 
 
Published:May 16, 2019
DOI:https://doi.org/10.1016/j.cmet.2019.05.008

Comments by Dr. Robert Lustig

A calorie is a calorie is a calorie; eat less and exercise more; any calorie can be part of a balanced diet. These are the mantras of the processed food industry. But are they real or fake news?

Hall and his NIH group attempted to answer this question with a 2-week crossover demand feeding study comparing the effects of real food (NOVA system class I, developed by Monteiro et al at the University of Sao Paolo) with ultra-processed food (NOVA system class IV). Hall locked up 20 subjects at the NIH Clinical Center, threw away the key, and fed them in random order and for 2 weeks at a time an ad lib processed food diet (more carbohydrate, less fiber) or an ad lib real food diet (less carbohydrate, more fiber). The two diets were matched for presented calories, sugar, fat, fiber, and macronutrients. Hall tracked food intake, body weight, energy expenditure, and baseline and glucose-stimulated hormonal parameters.

The ultra-processed food diet resulted both in weight gain and 508 calories per day greater intake (mostly carbohydrate) than the real food diet, which resulted in weight loss. The only things that distinguished the ingestion patterns were higher carbohydrate and less fiber in the ultra-processed diet. Finally, body weight changes correlated with changes in energy intake.

Bottom line: like other studies which preceded it (eg, the DIETFITS study), this study shows that real food works, and processed food doesn’t — take it to the bank. Real food resulted in fewer calories consumed, but we can’t infer that the effect was due to increased fiber (fewer calories absorbed); decreased energy density; reductions in carbohydrate; reductions in insulin and changes in leptin signaling; feeding the microbiome; and/or increased satiety.

And what about the food industry’s real versus fake news? Can we discern if, and which, macronutrients are the bad guys? What really reduced caloric intake? Unfortunately, this study was not designed or powered to assess whether certain macronutrients (like starch, fat, fructose) altered food intake apart from its caloric equivalent. Hall is a thermodynamics guy—and a calorie is always a calorie. So, don’t expect any other seminal answers out of this one.

Commentary originally published in PracticeUpdate! 

https://www.practiceupdate.com/content/ultra-processed-diets-cause-excess-calorie-intake-and-weight-gain/84403/65/8/1 

Citation:

Lustig RH. Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of ad Libitum Food Intake. PracticeUpdate website. Available at: https://www.practiceupdate.com/content/ultra-processed-diets-cause-excess-calorie-intake-and-weight-gain/84403/65/8/1. Accessed July 11, 2019 

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Another Note on Fiber

Another Note on Fiber

The fiber in real food is of two kinds: soluble, which is globular (e.g. beta-glucan, pectin, inulin, etc.); and insoluble, which is stringy (e.g. psyllium, cellulose, chitin, etc.). You need both, as they do different jobs. The insoluble fiber forms a latticework (like a fishing net) in the duodenum, and the soluble fiber plugs the holes in that latticework. Together they form a secondary barrier on the inside of the duodenum, which prevents early absorption of mono- and di-saccharides, as well as other readily absorbable nutrients.

Psyllium is an insoluble fiber. Alone It could form the latticework, but not plug the holes. Beta-glucan is a soluble fiber. It can swell and absorb water, but could not lay down the scaffolding. To get the benefits on delay of absorption, you would need both. Real food has both. Ingestion of either psyllium alone or beta-glucan alone could not form the secondary barrier. You need both. Could you put both into one pill? Perhaps. But the side-effects would be highly problematic.

Psyllium is not compressible, so in order to lay down the latticework for creation of the duodenal barrier, you would have to take a high dose of psyllium. Furthermore, psyllium leads to loose stools, which is not disastrous, but is not pleasant. Beta-glucan swells with exposure to water and does not release the water causing severe bloating, distress, and diarrhea. It does not absorb macronutrients, just water. Furthermore, neither fiber gives up the water it absorbs, resulting in problematic and persistent GI distress. 

Intact fiber – as a whole food – has many benefits. Not just the short-chain fatty acids (SCFAs). In the processed food industry, the “germ” of the grain (the nucleic acids, flavinoids, polyphenols) is removed with the fiber. Keeping the fiber also means keeping the germ intact. 

Cardiologist slams Government Dietary Advice in Parliamentary Speech

Cardiologist slams Government Dietary Advice in Parliamentary Speech

Dr. Aseem Malhotra addressed the European Parliament on February 26, 2019 – see the video recording to on the left side of this screen. You may view his powerpoint here as well.

“The science of reversing type 2 diabetes with a low carbohydrate diet (and overcoming opposition from vested interests)”

Aseem Malhotra Parliament Talk

Dr. Aseem Malhotra
Honorary Consultant Cardiologist, Lister Hospital Stevenage
Academy of Medical Royal Colleges Choosing Wisely Steering Group
King’s Fund – Member of Board of Trustees

(With special thanks to Professor Sir Muir Gray, Dr. Robert Lustig, Professor Simon Capewell, Dr. Kevin Hall, and Dr. David Unwin)

Dr. Malhotra pulls no punches.

“This evening I had the honor of speaking In parliament to a packed audience of MPs, lords, healthcare practitioners, and members of the public including Dr. Michael Moseley. There were no holds barred in calling out dietary misinformation coming from the establishment including Public Health England, ignorant scientists and the British Dietetic Association. Evidence based medicine has been hijacked by commercial influence but we have the solutions to fix this broken system and we must. It was also a pleasure to meet with a very receptive and friendly Secretary of State for health who was delighted to receive a copy of the Pioppi Diet. He also promised he would watch my talk and that of Dr. Zoe Harcombe that has been recorded by Ivor Cummins for you all to see soon. Special thank you to Tom Watson and Keith Vaz for making this happen!”

-Dr. Aseem Malhotra

Intro by MP Tom Watson