Food is Health

On September 30th, I will be a Keynote Speaker at the Crusonia on the Delta #FoodIsHealth Digital Forum. Crusonia has made Registration for the Forum FREE and encourages anyone passionate about the importance of healthy food to participate. You will be able to watch my conversation titled “FOOD IS HEALTH” live by registering here. I look forward to seeing you (digitally) at the Forum

Double Dose of Sugar

A double dose of sugar!

The Nature Metabolism paper explains why some people who eat high sugar diets get fatty liver and some don’t.

It has to do with “leaky gut”; those with leaky gut get NAFLD. Except that chronic fructose causes NAFLD!

The Cell Metabolism paper shows why fructose causes both liver fat AND oxidative stress.

Normally these are in different liver pathways. It turns out the cell has a switch called triose kinase, which directs fructose metabolites down one pathway or the other.

These two papers, taken together, drive home the assertion that fructose is the primary, and the most modifiable driver of fatty liver, insulin resistance, and metabolic syndrome.

It’s the processed food, D’oh!!

Fructose stimulated de novo lipogenesis is promoted by inflammation, Nature Metabolism

Triose Kinase Controls the Lipogenic Potential of Fructose and Dietary Tolerance, Cell Metabolism

Schematic summary from “Fructose stimulated de novo lipogenesis is promoted by inflammation.” In IEC, dietary fructose is converted to F1P by KHK. F1P inhibits protein N-glycosylation, triggering ER stress and intestinal inflammation to downregulate TJPs and trigger barrier deterioration and endotoxaemia. Endotoxin (LPS) reaches the liver via the portal vein and engages TLR4 on macrophages to activate nuclear factor kappa B (NF-κB) via the adaptor protein MyD88 and induce TNF expression and secretion. TNF engages TNFR1 on hepatocytes to induce caspase-2 (CASP2) mRNA, whose translation is stimulated by ER-stress-activated IRE-1. CASP2 activates SREBP1 to induce ACC1 and FAS, thereby priming the liver to convert KHK-generated F1P to FA (C:16, C:18), giving rise to hepatosteatosis. *P< 0.05; **P< 0.01; ***P< 0.001.

 

Wellness Bingo

Celebrate August being National Wellness Month!

Join the UCSF office of Wellness and Community in a UCSF Wellness Bingo Challenge to prioritize your wellbeing and self-care.

Throughout the month of August, pick and complete at least five of the activities in the Wellness Bingo Grid in any order. No need to actually stick to a diagonal or the same row or column – wellness is about being flexible too.

Submit your results in the Qualtrics link on the Bingo Grid and be entered in a drawing for a chance to win a $25 gift card. 10 winners will be selected!

Wellness Bingo Grid: https://campuslifeservices.ucsf.edu/upload/wellnesscommunity/files/Wellness_Bingo_Challenge.pdf

Qualtrics Submission Form: https://ucsf.co1.qualtrics.com/jfe/form/SV_eKikDNRPsBkgMn3

Click on the image below for the interactive (hyperlinked) PDF:

Myths Of Chronic Metabolic Disease

Join us for a FREE live webinar on Tuesday, August 11th at 3:00 pm EDT!
 

Two Myths Of Chronic Metabolic Disease: The Real Problem and the Simplex Solution

REGISTER HERE:

bit.ly/simplex_webinar

Simplex Health Medical Advisor Robert Lustig M.D., M.S.L. endocrinologist, best-selling author, and an Emeritus Professor of Pediatric Endocrinology at the University of California will dispel two common obesity myths and reveal what’s really responsible for fueling the chronic disease in our country today. Co-hosted by Simplex Health’s Chief Medical Officer and Medical Director, Avrahom Gurwitz M.D. MPH FAAP CPH IFM and Clinical Director of Diabetes Prevention & Reversal and Director of Protocol Research & Development Stephanie Biggs, RD LDN CDE, will discuss dietary strategies that target this problem for the purpose of preventing and reversing disease.

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