A double dose of sugar!
The Nature Metabolism paper explains why some people who eat high sugar diets get fatty liver and some don’t.
It has to do with “leaky gut”; those with leaky gut get NAFLD. Except that chronic fructose causes NAFLD!
The Cell Metabolism paper shows why fructose causes both liver fat AND oxidative stress.
Normally these are in different liver pathways. It turns out the cell has a switch called triose kinase, which directs fructose metabolites down one pathway or the other.
These two papers, taken together, drive home the assertion that fructose is the primary, and the most modifiable driver of fatty liver, insulin resistance, and metabolic syndrome.
It’s the processed food, D’oh!!
Fructose stimulated de novo lipogenesis is promoted by inflammation, Nature Metabolism
Schematic summary from “Fructose stimulated de novo lipogenesis is promoted by inflammation.” In IEC, dietary fructose is converted to F1P by KHK. F1P inhibits protein N-glycosylation, triggering ER stress and intestinal inflammation to downregulate TJPs and trigger barrier deterioration and endotoxaemia. Endotoxin (LPS) reaches the liver via the portal vein and engages TLR4 on macrophages to activate nuclear factor kappa B (NF-κB) via the adaptor protein MyD88 and induce TNF expression and secretion. TNF engages TNFR1 on hepatocytes to induce caspase-2 (CASP2) mRNA, whose translation is stimulated by ER-stress-activated IRE-1. CASP2 activates SREBP1 to induce ACC1 and FAS, thereby priming the liver to convert KHK-generated F1P to FA (C:16, C:18), giving rise to hepatosteatosis. *P< 0.05; **P< 0.01; ***P< 0.001.
Celebrate August being National Wellness Month!
Join the UCSF office of Wellness and Community in a UCSF Wellness Bingo Challenge to prioritize your wellbeing and self-care.
Throughout the month of August, pick and complete at least five of the activities in the Wellness Bingo Grid in any order. No need to actually stick to a diagonal or the same row or column – wellness is about being flexible too.
Submit your results in the Qualtrics link on the Bingo Grid and be entered in a drawing for a chance to win a $25 gift card. 10 winners will be selected!
Qualtrics Submission Form: https://ucsf.co1.qualtrics.com/jfe/form/SV_eKikDNRPsBkgMn3
Click on the image below for the interactive (hyperlinked) PDF:
Two Myths Of Chronic Metabolic Disease: The Real Problem and the Simplex Solution
Simplex Health Medical Advisor Robert Lustig M.D., M.S.L. endocrinologist, best-selling author, and an Emeritus Professor of Pediatric Endocrinology at the University of California will dispel two common obesity myths and reveal what’s really responsible for fueling the chronic disease in our country today. Co-hosted by Simplex Health’s Chief Medical Officer and Medical Director, Avrahom Gurwitz M.D. MPH FAAP CPH IFM and Clinical Director of Diabetes Prevention & Reversal and Director of Protocol Research & Development Stephanie Biggs, RD LDN CDE, will discuss dietary strategies that target this problem for the purpose of preventing and reversing disease.
I’m very happy to recommend Michael Goran and Elsie Ventura’s new book “Sugarproof” for two reasons. First, it’s yet another piece lifted out of the Jenga that the sugar industry compiled in the 1970’s, and the structure is finally tumbling down. Second, earlier in his career, Michael researched exercise. But he switched to sugar, because he realized no matter how we try otherwise, we can’t outrun a bad diet, and not even our kids can. Diet is the #1 problem. And sugar is public enemy #1.
Please join us for a live discussion with Sugarproof authors Drs. Goran & Ventura at https://www.facebook.com/DrRobertLustig: How sugar disrupts growth and development and how to empower families to consume less.